The biggest culprit that creates a conflict with the registered keys on LightShot is OneDrive. To access it, you can apply a shortcut by clicking Win + E keys on your keyboard.

You can check whether the hotkeys are already registered on another program by using a program like Windows Hotkey Explorer. However, Lightshot cannot register or use the following hotkeys if they are already in use by other programs: Some hotkeys are usually preset in a program and are also commonly applied by most users. They are: Solution#1: Check if another program has registered the hotkey Here are a few solutions you can apply to help you solve this issue. You are using an old build of Lightshot.You are using an old version of Windows.A separate program has registered the hotkey.Here are some of the reasons why Lightshot may fail to register a hotkey: When this happens, you will get the message: “Lightshot failed to register hotkey!” As versatile as it may be, it sometimes may not register a hotkey thereby shutting down its functions and leaving you unable to take screenshots.

How to edit lightshot settings